Recombinant Human S100B
產(chǎn)品編號(hào)：RXS007Ag*C-1000
加入購(gòu)物車SPECIFICATIONS
- Product name Recombinant Human S100B
- Source E.coli derived
- Accession # P04271
- SDS-PAGE 12kDa, reducing conditions.
- N-terminal Sequence Ala
- Predicted Molecular Mass 12.2kDa
- Activity Measured by its ability to combine Human S100B Antibody.
- Endotoxin Level /
- Application ELISA, standards, quality controls, others unspecified.
- Form Liquid
- Formulation Lyophilized from a 0.2 μm filtered solution of 20mM Tris, 150mM NaCl, pH 7.4
- Stability & Storage Reconstituted protein solution should be stored at ≤ -20°C.Stable for at least 24 months when stored as instructed.
- Shipping condition The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended front.
- Lot number 20230428
- Concentration /
- Conc. Determined BCA
- Purity >90%
S100B, is an acidic protein with a molecular weight of 21 kDa belonging to the S100 family. S100-B contains two EF-hand-type calcium-binding motifs separated by a hinge region with a hydrophobic cleft. S100-B plays an important role in neurodevelopment, differentiation, and brain construction. S100-B has neuroprotective effects, but at high concentrations S100-B is neurotoxic. Extracellular concentration of S100-B increases following brain damage, which easily penetrates into cerebrospinal fluid in brain damage and then into the blood. S100-B is expressed and produced by astrocytes in vertebrate brains and in the CNS, and the astrocytes are the major cells producing S100-B protein in gray matter, as well as oligodendrocytes are the predominant S100-B in protein producing cells in white matter. The major advantage of using S100-B is that elevations in serum or CSF levels provide a sensitive measure for determining CNS injury at the molecular level before gross changes develop, enabling timely delivery of crucial medical intervention before irreversible damage occurs. In addition, S100-B, which is also present in human melanocytes, is a reliable marker for melanoma malignancy both in bioptic tissue and in serum.
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